Relationship between blood pressure and cognitive decline in normal cognitive population: A four‐year follow‐up study in rural Xi'an

Background Hypertension is a modifiable risk factor for cognitive impairment, although the relationship between hypertension and impairment not fully understood. The objective of to clarify blood pressure decline in normal population through longitudinal follow-up study. Method Cognitively was selected from people who lived suburbs Xi’an, China.The mini-mental state examination (MMSE) neuropsychological battery were used assess cognition. Four years later, MMSE tested again defined as decrease scores ≥2 points.The parameters [systolic (SBP), diastolic (DBP), mean arterial (MABP),] analyzed by logistic regression models using interaction stratified analysis. Blood age regarded both continuous categorical data。 Result A total 1024 participants completed study, among whom 168 subjects (16.41%) presented decline.Interaction analysis showed that SBP (when data) positively correlated with (OR = 1.173 [95% CI,1.030-1.335] per 10mmHg, P 0.016); however, term inclined be negatively 0.850 CI, 0.711–1.016] per10mmHg×year, 0.074), indicating age-dependent. When considered binary data, results similar those obtained when they variables.Stratified multivariate revealed positive patients aged 50-59 1.209 CI:1.025–1.427] 0.024).However, DBP MABP. Conclusion Elevated middle age(50-59), but this association declines increasing age.